MS12.02 Clinical Data Available

Project data sphere to make cancer clinical trial data publicly available.

I n the mid-1980s, the emerging semiconductor industry had a problem. Many competing standards and manufacturing practices were a costly drag on progress. U.S. chipmakers realized that solving common problems and developing industry-wide standards would benefit everyone. They created Sematech, a joint venture that helped solve thorny technical challenges and yielded industry-wide efficiencies t...

Clinical Applicability of Stem Cell Therapy in Dental Diseases: A Systematic Review of Available Clinical Trials

Background: Developing cell-based therapeutic methods for the differentiation of various stem cells to the dental tissues could be a revolutionary step towards the use of cell therapy for dental disease. In the present study, we aimed to systematically review the literature to establish the efficiency of stem cells in treatment of various dental diseases. Methods: A literature search was perfo...

Assessing Clinical Efficacy of Available Antihypertensive Agents

Gene medicine for cancer treatment: Commercially available medicine and accumulated clinical data in China

Loss of p53 function compromises genetic homeostasis, which induces deregulated DNA replication, damages DNA, and subsequently results in increased resistance to anticancer agents. Pharmacological approaches using recombinant adenoviruses (Ad) have been developed to restore the p53 functions. Another approach for gene medicine is to modify Ad replication in a tumor-specific manner, which induce...

Database integration of 4923 publicly-available samples of breast cancer molecular and clinical data

We outline a paradigm for meta-microarray database creation and integration with clinical variables. We use as our implementation example a breast cancer database linking RNA expression measurements (by microarray) and clinical variables, such as survival metrics and tumor size. Such an endeavor involves integrating across different microarray datasets as well as clinical parameters. To this en...